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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Biomarkers.

Ana Paula Bernardes Real1,2,3, Arthur C Macedo1,4,5,6, Wyllians Vendramini Borelli7,8

  • 1McGill University, Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

Plasma p-tau217 levels may be linked to Mild Behavioral Impairment (MBI) symptoms like impulse control issues in older adults. However, cognitive status appears to be a stronger predictor of these changes.

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Area of Science:

  • Neuroscience
  • Biomarker Research
  • Gerontology

Background:

  • Mild Behavioral Impairment (MBI) comprises late-onset neuropsychiatric symptoms in predementia populations.
  • Previous research linked amyloid PET to MBI but not tau PET.
  • The role of plasma biomarkers, like p-tau217, in MBI is not well understood.

Purpose of the Study:

  • To investigate the association between plasma p-tau217 levels and MBI in older adults without dementia.
  • To explore specific MBI domains related to plasma p-tau217.

Main Methods:

  • 168 older adults (cognitively unimpaired and mild cognitive impairment) were analyzed.
  • Amyloid status was assessed using [18F]AZD4694 Aβ-PET.
  • Plasma p-tau217 was measured using the Janssen Simoa Assay; MBI was assessed with the MBI-C.

Main Results:

  • Higher plasma p-tau217 levels correlated with increased MBI total score, emotion dysregulation, and impulse dyscontrol.
  • These associations lost significance when cognitive status (CDR-SB) was factored in.
  • MBI symptoms were primarily associated with cognitive status.

Conclusions:

  • Plasma p-tau217 may influence MBI, particularly impulse and emotion dysregulation.
  • Cognitive status is the most significant predictor of these behavioral symptoms in older adults.
  • Further research is needed to understand the interplay between p-tau217, cognitive decline, and MBI.