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Noncardiovascular Medical Conditions in the Pregnancy Mortality Surveillance System, 2012-2022
Fanny Njie1, Ashley A Busacker, Crystal Gibson
1Tanaq Support Services, LLC, St. George Island, Alaska; and the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Obstetrics and Gynecology
|January 22, 2026
Summary
Pregnancy-related deaths from other noncardiovascular medical conditions (OMC) were analyzed. Epilepsy, diabetes, and asthma were the most frequent causes, highlighting the need for targeted interventions.
Area of Science:
- Public Health
- Epidemiology
- Maternal Health
Background:
- Pregnancy-related deaths from "other noncardiovascular medical conditions" (OMC) represent a significant public health concern.
- Understanding the specific causes within OMC is crucial for effective intervention strategies.
Purpose of the Study:
- To analyze pregnancy-related deaths attributed to OMC using Pregnancy Mortality Surveillance System (PMSS) data from 2012-2022.
- To identify and compare the most frequent subcategories of OMC deaths during prepandemic and pandemic periods.
Main Methods:
- Descriptive analysis of PMSS data (2012-2022).
- Calculation of pregnancy-related mortality ratios (PRMRs) for OMC subcategories.
- Stratification of data into prepandemic (2012-2019) and COVID-19 pandemic (2020-2022) periods.
Main Results:
- The overall OMC-specific PRMR was 2.20 deaths per 100,000 live births.
- Epilepsy was the most frequent OMC subclassification both prepandemic (15.7%) and during the pandemic (16.1%).
- Diabetes and asthma were the next most common causes, with slight shifts in ranking between the two periods.
Conclusions:
- Detailed subclassifications of pregnancy-related deaths within OMC are essential for targeted public health interventions.
- Consistent identification of leading causes like epilepsy, diabetes, and asthma can guide focused prevention efforts.
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