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Updated: Jan 24, 2026
Transient Transduction of the Strobilated Forms of Echinococcus granulosus
Published on: September 16, 2022
Primary evaluation of immune responses in mice after a single mRNA immunization with Echinococcus granulosus Eg95 and
Chun-Ni Meng1, Ting-Ting Li2, Wen-Hui Li2
1State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; Gansu Agricultural University, Lanzhou 730070, China.
Abstract:
Echinococcus granulosus and Taenia multiceps cause zoonotic cystic diseases. Studies have shown that Eg95 from E. granulosus is highly conserved, exhibits excellent immunogenicity, and serves as a critical candidate antigen. In recent years, the TM16 recombinant protein antigen has been one of the most studied antigens for preventing C. cerebralis and demonstrates optimal experimental immunogenicity. This study developed both recombinant protein and mRNA-LNP vaccines targeting the Eg95 and TM16 antigens. Immunization of BALB/c mice showed that both vaccines significantly increased specific antibody levels (IgG, IgG1, IgG2a) and cytokines (IFN-γ, IL-4) (P < 0.001), inducing a predominant Th1-type immune response. The mRNA-LNP vaccine demonstrated superior efficacy in enhancing IgG2a levels and CD8+ T cell responses compared to the protein vaccine. These results indicate strong immunogenicity and support further evaluation of the Eg95-TM16 mRNA-LNP vaccine in intermediate hosts like sheep and goats.
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