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PRRSV nucleocapsid and nonstructural proteins dual-regulate CD40 expression via ATF-2 and AP-1 pathways

Chaolun Fu1, Hongyan Gao1, Yingchao Li1

  • 1College of Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China.

Veterinary Microbiology
|January 22, 2026
PubMed
Summary

Porcine reproductive and respiratory syndrome virus (PRRSV) alters macrophage CD40 expression. PRRSV nucleocapsid protein upregulates CD40, while other viral proteins downregulate it, offering potential antiviral targets.

Keywords:
AP-1ATF-2Anti-viral drugCD40Nonstructural proteinsNucleocapsid proteinPRRSV

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