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Updated: Jan 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Design, synthesis and biological evaluation of new ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) derivatives as

Chenliang Zhao1, Yinxiao Du2, Yixuan Xia3

  • 1Guizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, 50 Cityeast Road, Guiyang, Guizhou 550002, PR China; School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China.

Bioorganic & Medicinal Chemistry
|January 22, 2026
PubMed

Keywords:
5F derivatives5F ent-kaurene diterpeneCytotoxicityHCT116 mouse modelIn vivo antitumor activity

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