Related Experiment Video
Updated: Jul 28, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Difficulties measuring a polypharmacy quality indicator in Switzerland's residential long-term care institutions - a
Magdalena Osińska1, Carla Meyer-Massetti2, Naomi Welte3
1Institute of Nursing Science, Departement Public Health, Faculty of Medicine, University of Basel, Bernoullistr, 28, 4056 Basel, Switzerland.
None:
Polypharmacy is widespread in residential long-term care (RLTC), increasing the risk of medication-related problems. Switzerland's RLTC institutions must report polypharmacy (defined as ≥ 9 active substances) as part of a national health-care quality indicator (QI) initiative. This sequential explanatory mixed-methods study assessed the quality of data collected to calculate a polypharmacy QI across 14 RLTC institutions in German-speaking Switzerland, aiming to recommend improvements. A validation study assessed inter-rater reliability, subsequently, medication lists of individual patients with different medication counts were discussed with RLTC staff to explore the issues affecting those calculations. Institutions and study researchers calculated different numbers of active substances in 65.3 % of the 580 residents assessed, and recorded an overall prevalence of polypharmacy of 45.5 % and 47.4 %, respectively. Solid master data, unambiguous counting rules, and electronic algorithms are necessary to calculate reliable polypharmacy QIs. Additional measures, like medication reviews, might facilitate distinctions between appropriate and inappropriate polypharmacy.
Related Concept Videos
Measurement of Bioavailability: Pharmacokinetic Methods
Measurement of Bioavailability: Pharmacodynamic Methods
Dosage Regimen: Individualization
Therapeutic Drug Monitoring: Drug Analysis Methods

