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Updated: Jan 24, 2026
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A multi-region recurrent circuit for evidence accumulation in rats
Diksha Gupta1, Charles D Kopec1, Adrian G Bondy1
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Neuron
|January 22, 2026
Summary
Rats
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- Decision-making involves evidence accumulation and categorization.
- A feedforward model proposed anterior dorsal striatum (ADS) for accumulation and frontal orienting fields (FOF) for categorization.
Purpose of the Study:
- To investigate the roles of ADS and FOF in evidence accumulation and categorization.
- To challenge the proposed feedforward model of decision-making.
Main Methods:
- Electrophysiological recordings and neural decoding in rats.
- Optogenetic manipulation (silencing) of FOF projections to ADS and nonselective FOF silencing.
- Development and analysis of a multi-region recurrent neural network model.
Main Results:
- ADS and FOF exhibit similar encoding/decoding of evidence accumulation value.
- Bidirectional communication observed between ADS and FOF.
- Silencing FOF to ADS projections, but not nonselective FOF silencing, affected behavior throughout accumulation.
- In silico experiments showed recurrent connections in the cortico-striatal circuit confer robustness to perturbations.
Conclusions:
- Evidence accumulation and categorization are not strictly modular but involve distributed and recurrent processing between ADS and FOF.
- The cortico-striatal circuit exhibits redundant representations and robustness to perturbations due to recurrent dynamics.
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