Related Experiment Video
Updated: Jan 24, 2026
12:45
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
6.4K
Locally Recurrent Rectal Cancer in the Lateral Compartment: Imaging Features and Association with Primary Tumour
F E C Vande Kerckhove1,2, D M J Creemers3,4, E Banken4,5
1Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands. fleur.v.kerckhove@catharinaziekenhuis.nl.
Annals of Surgical Oncology
|January 22, 2026
Summary
Locally recurrent rectal cancer (LRRC) is often linked to factors beyond lateral lymph node (LLN) metastasis. Most lateral LRRC cases stem from primary tumor spread and other high-risk features, indicating a complex cause.
Area of Science:
- Colorectal Surgery
- Surgical Oncology
- Radiology
Background:
- Locally recurrent rectal cancer (LRRC) in the lateral pelvic compartment signifies a poor prognosis.
- The specific causes, including lateral lymph node (LLN) metastases or other high-risk features, are not fully understood.
Purpose of the Study:
- To investigate the features of lateral LRRC.
- To explore the anatomical associations between lateral LRRC and primary tumor characteristics.
Main Methods:
- Retrospective analysis of 104 patients with lateral LRRC (2018-2025).
- Central re-review of primary and recurrent tumor MRIs to assess features.
- Expert panel evaluation of anatomical relationships between primary tumors and lateral recurrence sites.
Main Results:
- High prevalence of high-risk features in primary tumors: extramural vascular invasion (45%), advanced staging (47%), tumor deposits (23%), and pathological LLNs (20%).
- Patients with pathological LLNs in primary tumors showed increased synchronous high-risk features.
- Only 11% of lateral LRRC cases were linked to primary LLNs; 89% were attributed to other causes.
Conclusions:
- A minority of lateral LRRC cases are attributable to primary lateral lymph node involvement.
- The majority of lateral LRRC cases likely have a multifactorial etiology, related to primary tumor spread and other high-risk features.
More Related Videos
Related Concept Videos
01:27Assessing Body Temperature - Rectal
11.8K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
11.8K
01:23Characteristics of Life
257.3K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
257.3K
01:20Compartment Models: Two-Compartment Model
7.0K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.0K
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
01:06Three-Compartment Open Model
871
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
871
01:14Compartment Models: Single-Compartment Model
3.1K
The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
3.1K