Prevalence of Macrolide-resistant Mycoplasma pneumoniae in Children and Adolescents with Community-acquired Pneumonia: A Prospective Study in Thailand
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View abstract on PubMed
Summary
This summary is machine-generated.Macrolide-resistant Mycoplasma pneumoniae (MRMP) causes about 1 in 5 pediatric community-acquired pneumonia cases in Thailand, leading to delayed recovery. Monitoring MRMP is essential for effective pediatric CAP treatment strategies.
Area Of Science
- Pediatric Infectious Diseases
- Microbiology
- Respiratory Medicine
Background
- Community-acquired pneumonia (CAP) is a significant pediatric illness.
- Mycoplasma pneumoniae is a common cause of pediatric CAP.
- The rise of macrolide-resistant M. pneumoniae (MRMP) poses a treatment challenge.
Purpose Of The Study
- To determine the prevalence of MRMP-induced pediatric CAP in Bangkok, Thailand.
- To investigate the clinical characteristics and outcomes of MRMP infections.
- To inform local treatment strategies for pediatric CAP.
Main Methods
- Prospective collection of nasopharyngeal aspirates from children (0-18 years) with radiograph-confirmed CAP.
- Identification of M. pneumoniae using real-time PCR (RT-PCR).
- Detection of macrolide-resistant mutations (A2063G, A2064G, A2067G, C2617G) via PCR-sequencing.
Main Results
- M. pneumoniae was detected in 16.6% of 332 pediatric CAP cases.
- MRMP was identified in 22.2% of genotyped M. pneumoniae infections (all A2063G mutations).
- Patients with MRMP experienced a significantly longer time to defervescence (5.5 days vs. 3.0 days, P=0.003) compared to non-resistant strains.
Conclusions
- Approximately 20% of pediatric mycoplasmal CAP cases in Thailand are caused by MRMP.
- MRMP infections are associated with prolonged fever resolution.
- Surveillance of MRMP is critical for developing effective pediatric CAP management guidelines.
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