Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

16.0K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.0K
Improving Translational Accuracy02:07

Improving Translational Accuracy

14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.6K
3.6K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.4K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

100.5K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
100.5K
Interfacial Electrochemical Methods: Overview01:06

Interfacial Electrochemical Methods: Overview

820
Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current...
820

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allogeneic hematopoietic stem cell transplantation for a pediatric case of myelodysplastic syndrome with germline DDX41 mutation.

Annals of hematology·2026
Same author

Single-Mode Capability Enhancement of Curved Sapphire Fiber Utilizing High-Order Mode Suppression Characteristics Applied at High Temperature.

Micromachines·2026
Same author

Dynamic Changes and Future Trend Forecasts in the Global Burden of Guillain-Barré Syndrome: Analysis of 204 Countries and Regions From 1990 to 2021, Including the Impact of the COVID-19 Pandemic.

Immunity, inflammation and disease·2026
Same author

Venocentric perspective on varicocele: summarizing mechanisms and explorations.

Frontiers in physiology·2026
Same author

Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of childhood asthma and obesity.

Translational pediatrics·2026
Same author

Human CD24<sup>+</sup> dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis.

Nature communications·2026
Same journal

Nanomaterial-Decorated Biomass-Derived Carbon for Electrochemical Sensing: Design Principles, Interfacial Mechanisms, and Practical Applications.

Chemical record (New York, N.Y.)·2026
Same journal

Enantioselective Construction of Bridged Biaryl Atropisomers With Medium- and Macrocyclic Architectures.

Chemical record (New York, N.Y.)·2026
Same journal

From Ions to Biomolecules and Beyond: Versatile Starburst Triphenylamine-Based Scaffolds as Multifunctional Tools for Advanced Sensing Applications.

Chemical record (New York, N.Y.)·2026
Same journal

Recent Advances in the Synthesis of 1,4-Enynes and Their Applications in Organic Synthesis.

Chemical record (New York, N.Y.)·2026
Same journal

Surface Mounted Metal-Organic Frameworks for Advanced Sensing: Construction Strategies, Recent Applications, and Emerging Opportunities With Artificial Intelligence.

Chemical record (New York, N.Y.)·2026
Same journal

Advances in Spinel Ferrite Photocatalysts: From Synthesis, Fundamental Mechanisms, and Solar Energy Conversion Applications.

Chemical record (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays
12:25

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays

Published on: March 3, 2014

16.5K

Interfacial Modification of Nanochannels for Enhanced Detection Accuracy in Complex Matrices.

Tiantian Hu1, Yushun Deng1, Yu Liao1

  • 1Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.

Chemical Record (New York, N.Y.)
|January 23, 2026
PubMed
Summary
This summary is machine-generated.

Interfacial modification enhances solid-state nanochannels (SSNs) for precise single-molecule detection in complex samples. Strategies improve stability, specific recognition, and signal amplification for advanced environmental and biomedical applications.

Keywords:
complex matricesdetection accuracyinterfacial modificationnanochannels

More Related Videos

Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes
06:36

Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes

Published on: July 28, 2017

12.5K
Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

24.6K

Related Experiment Videos

Last Updated: Jan 24, 2026

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays
12:25

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays

Published on: March 3, 2014

16.5K
Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes
06:36

Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes

Published on: July 28, 2017

12.5K
Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

24.6K

Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Solid-state nanochannels (SSNs) offer potential for single-molecule sensing in diverse fields.
  • Challenges in complex matrices include nonspecific adsorption, ion competition, and background noise.
  • Interfacial modification presents effective solutions to overcome these limitations.

Purpose of the Study:

  • To review interfacial engineering methods for solid-state nanochannels.
  • To focus on strategies for stability enhancement, specific recognition, and signal amplification.
  • To outline future perspectives for high-precision detection in complex matrices.

Main Methods:

  • Review of interfacial modification strategies for SSNs.
  • Categorization of methods into stability enhancement, specific recognition, and signal amplification.
  • Highlighting techniques like antifouling coatings, biomimetic engineering, and nanotag-assisted amplification.

Main Results:

  • Interfacial modification significantly improves SSN performance in complex environments.
  • Stability enhancement methods include antifouling coatings and covalent crosslinking.
  • Specific recognition is achieved through structure-adaptive modification and biomimetic engineering.
  • Signal amplification techniques involve in situ amplification and catalysis-mediated methods.

Conclusions:

  • Interfacial modification is crucial for advancing SSN-based detection.
  • Integration with multidisciplinary approaches will drive high-precision sensing.
  • Future directions involve AI-driven signal processing and advanced nanomaterials.