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Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
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A patent review on traumatic brain injuries (2020-2025)
Khyati Sharma1, Deepak Agrawal2, Reema Gabrani1
1Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.
The International Journal of Neuroscience
|January 23, 2026
Summary
Recent patent activity shows advancements in traumatic brain injury (TBI) diagnostics and therapeutics. Innovations focus on early detection via biomarkers and multimodal strategies for neuroprotection and recovery.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- Traumatic brain injury (TBI) is a major cause of death and disability globally.
- Current treatments for TBI are limited, lacking the ability to halt or reverse secondary injury cascades.
- There is a critical need for novel diagnostic and therapeutic strategies for TBI.
Purpose of the Study:
- To review recent patent activity (2020-2025) in traumatic brain injury (TBI).
- To highlight innovations in TBI diagnostics, biomarker integration, and therapeutic strategies.
- To assess the translational potential and future directions of TBI research and development.
Main Methods:
- Analysis of patent literature from 2020-2025 focusing on TBI.
- Categorization of patents into diagnostic innovations, biomarker integration, and therapeutic strategies.
- Review of expert opinions on emerging technologies and their clinical applicability.
Main Results:
- Diagnostic patents feature multimodal platforms combining biomarkers (GFAP, UCH-L1, NfL, p-tau), imaging, and physiological monitoring for early detection and stratification.
- Therapeutic patents cover anti-inflammatory agents, metabolic stabilizers, regenerative approaches, and advanced drug delivery systems.
- Multimodal therapeutic strategies integrating neuroprotection, neuro-restoration, and functional recovery are emerging.
- Non-invasive diagnostic technologies like breath sensors and eye-tracking are advancing point-of-care testing.
Conclusions:
- Recent patent activity reflects significant progress in TBI diagnostics and therapeutics.
- Biomarker-driven diagnostics show translational value for point-of-care testing and treatment guidance.
- Therapeutic innovations, while promising, are largely in early clinical or preclinical stages.
- Multimodal and regenerative approaches represent the future of TBI treatment development.
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