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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
Published on: June 14, 2018
Neuroinflammation in GAD65 Antibody-Associated Epilepsy Measured Using [18F]DPA-714 PET/MRI
Jingjing Chen1, Yuying Zhang2, Heyu Zhang1
1Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Abstract:
The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA-714 and PET to evaluate brain microglial activation. [18F]DPA-714 PET brain images of 11 patients with GAD65 antibody-associated epilepsy and seven controls were analyzed. Patients with acute symptomatic seizures presented higher [18F]DPA-714 SUVR in the hippocampus than did controls and patients with chronic temporal lobe epilepsy. Our findings highlight that [18F]DPA-714 PET/MRI represents a useful tool to assess neuroinflammation in patients with GAD65 antibody-associated epilepsy.
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