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Related Experiment Video

Updated: Jan 24, 2026

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Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.

Stefan Bräuer1,2, Verena Sondermann1,2, Iñaki Schniewind1,2

  • 1Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 23, 2026
PubMed
Summary

A new quantitative alpha-synuclein seed amplification assay (qnSAA) shows promise for detecting Lewy body pathology. This quantitative assay offers improved prognostic relevance for dementia risk compared to standard binary tests.

Keywords:
Alzheimer´s diseaseLewy bodyalpha‐synucleindementiareal‐time quaking‐induced conversionseed amplification assay

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Diagnostics

Background:

  • Alpha-synuclein seed amplification assay (SAA) detects Lewy body pathology in CSF.
  • Lewy body pathology is a key indicator for dementia risk.
  • Current SAA methods yield binary results, lacking quantification of pathology extent.

Purpose of the Study:

  • To develop and validate a quantitative SAA (qnSAA) for measuring alpha-synuclein pathology.
  • To assess the prognostic relevance of qnSAA in patients at risk for dementia.

Main Methods:

  • Developed a quantitative seed amplification assay (qnSAA).
  • Analyzed 432 CSF samples, including 216 baseline-follow-up pairs.

Main Results:

  • qnSAA results demonstrated a correlation with cognitive performance.
  • Fast qnSAA kinetics were observed in 75% of participants who converted to dementia.
  • Individuals with fast qnSAA kinetics represented 27.3% of all dementia converters.

Conclusions:

  • qnSAA measurements show significant prognostic value in dementia risk assessment.
  • qnSAA has potential for quantifying Lewy body pathology and monitoring therapeutic interventions.