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The 'Slide-by-Side' Full-Thickness Skin Graft for Large Donor Site Closure

Olivia G Cohen1, Margaret G Mercante1, Yusrat Ahsanullah2

  • 1Department of Dermatology, University of Virginia Health System, Charlottesville, Virginia, USA.

The Australasian Journal of Dermatology
|January 23, 2026
PubMed

Keywords:
Mohs micrographic surgerycosmetic reconstructive surgerydermatologic surgeryfacial reconstructionfull‐thickness skin graft

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...