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A reference centre experience in central Anatolia in terms of causes, severity and treatment of childhood anaphylaxis

Turan Guzel1, Halime Ermistekin2, Serdar Goktas2

  • 1Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkiye.

Northern Clinics of Istanbul
|January 23, 2026
PubMed

Insights

This study highlights key anaphylaxis triggers in children, including food, drugs, and venom, emphasizing prompt treatment with adrenaline for better outcomes. Recognizing these factors is crucial for managing this severe allergic reaction.

Area of Science:

  • Pediatric Allergy and Immunology
  • Emergency Medicine
  • Clinical Research

Background:

  • Anaphylaxis is a severe, potentially life-threatening allergic reaction affecting all age groups.
  • Distinct differences exist in causative factors, incidence, and severity of anaphylaxis between pediatric and adult populations.
  • Existing literature on childhood anaphylaxis is limited, necessitating further research.

Purpose of the Study:

  • To analyze the characteristics, triggers, and management of anaphylaxis in pediatric patients.
  • To contribute valuable data to the existing body of literature on childhood anaphylaxis.
  • To identify factors influencing anaphylaxis severity and treatment timeliness in children.

Main Methods:

  • Retrospective analysis of pediatric patients (0-18 years) diagnosed with anaphylaxis.
  • Data collected from the Pediatric Allergy Outpatient Clinic at Erciyes University between 2015 and 2021.
  • Inclusion criteria: diagnosis of anaphylaxis.

Main Results:

  • Anaphylaxis predominantly affected males, with females showing higher prevalence in adolescence.
  • Common triggers included venom (35.22%), food (27.84%), and drugs (23.29%).
  • Drug-induced anaphylaxis correlated with increased symptom severity; antibiotic and wasp sting anaphylaxis had rapid onset.

Conclusions:

  • Anaphylaxis is reversible with timely diagnosis and prompt treatment, particularly intramuscular adrenaline.
  • Recognizing common triggers and risk factors is essential for effective anaphylaxis management in children.
  • This study provides critical insights to improve anaphylaxis care and address management deficiencies.
Abstract

Keywords:
Adrenalineanaphylaxischildhood anaphylaxisseverity of anaphylaxistrigger

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