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Bioactives and exercise synergize to modulate AMPK and inflammation
ZhaoHui Sheng1, Quan Luo1, XianChu Liu1
1School of Physical Education, Hunan University of Arts and Science, Changde, Hunan, China.
Frontiers in Immunology
|January 23, 2026
Summary
Combining plant bioactives with exercise boosts AMP-activated protein kinase (AMPK) signaling. This enhances metabolism and immunity, offering potential for treating metabolic and neurodegenerative diseases.
Area of Science:
- Immunometabolism
- Molecular Biology
- Exercise Physiology
Background:
- AMP-activated protein kinase (AMPK) is crucial for energy balance and immune function.
- AMPK is a therapeutic target for obesity, insulin resistance, and neurodegenerative conditions.
- Plant bioactives and exercise modulate AMPK signaling.
Purpose of the Study:
- To review the synergistic effects of plant bioactives and exercise on AMPK signaling.
- To examine metabolic and immunological outcomes of combined interventions.
- To identify therapeutic potential in various tissues.
Main Methods:
- Systematic literature search across PubMed, Scopus, and Web of Science.
- Analysis of 14 preclinical studies.
- Focus on AMPK phosphorylation, mitochondrial biogenesis, glucose uptake, lipid oxidation, and inflammatory markers.
Main Results:
- Combined interventions significantly enhance AMPK phosphorylation and downstream metabolic pathways.
- Synergistic effects improve mitochondrial function, glucose uptake, and lipid metabolism.
- Reduced pro-inflammatory cytokines (TNF-α, IL-6) and NF-κB signaling observed via SIRT1/PGC-1α/Nrf2.
- Positive tissue-specific effects noted in muscle, heart, brain, liver, and adipose tissue.
Conclusions:
- Combined plant bioactives and exercise show significant therapeutic potential for immunometabolic disorders.
- Further mechanistic research, including epigenetics, is needed for personalized non-pharmacological strategies.
- Optimizing interventions requires more clinical data and understanding of tissue-specific responses.
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