Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

6.5K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
6.5K
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

3.7K
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.7K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

3.9K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
3.9K
Joints01:26

Joints

35.5K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.5K
Introduction to Joints00:58

Introduction to Joints

4.7K
The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
4.7K
Ankle Joint01:10

Ankle Joint

2.9K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.

Experimental & molecular medicine·2026
Same author

The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a during postnatal development.

Development (Cambridge, England)·2026
Same author

Correction: Synergistic protective and regenerative effects of hyaluronic acid and polynucleotides against UVA-induced oxidative stress in dermal fibroblasts.

Scientific reports·2026
Same author

Anti-senescence Effects of Nanovesicles Derived from Cluster of Differentiation-146-Positive Tonsil Mesenchymal Stem Cells via Modulation of the Tumor Protein 53 Pathway.

Biomaterials research·2026
Same author

Single-Port Robotic Pulmonary Resection for Non-Small-Cell Lung Cancer After Neoadjuvant Chemoimmunotherapy.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

GCC2 in Small Extracellular Vesicles as a Diagnostic and Prognostic Biomarker of Early-Stage Lung Adenocarcinoma.

Journal of extracellular vesicles·2026

Related Experiment Video

Updated: Jan 24, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

680

Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven

Jer-En Hsu, Qingyang Zhao, Weiqiu Cheng

    Biorxiv : the Preprint Server for Biology
    |January 23, 2026
    PubMed
    Summary

    Skeletal muscle myopathies are better understood by linking histopathology to molecular states using Seq-Scope. mTORC1 hyperactivation causes distinct fiber-type-dependent muscle pathologies and non-myocyte accumulation.

    More Related Videos

    Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
    07:40

    Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

    Published on: May 16, 2025

    921
    Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
    07:43

    Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

    Published on: May 3, 2024

    4.4K

    Related Experiment Videos

    Last Updated: Jan 24, 2026

    Mining Spatial Transcriptomics Datasets using DeepSpaceDB
    10:16

    Mining Spatial Transcriptomics Datasets using DeepSpaceDB

    Published on: September 5, 2025

    680
    Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
    07:40

    Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

    Published on: May 16, 2025

    921
    Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
    07:43

    Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

    Published on: May 3, 2024

    4.4K

    Area of Science:

    • Muscle biology
    • Molecular pathology
    • Systems biology

    Background:

    • Myopathies are diverse muscle diseases with unknown mechanisms, partly due to limitations in linking histopathology to molecular states at single-fiber resolution.
    • Understanding these mechanisms requires advanced techniques to analyze heterogeneous muscle tissue.

    Purpose of the Study:

    • To investigate the molecular mechanisms driving muscle pathologies in a rodent model of mTORC1 hyperactivation.
    • To link histopathological features to molecular states at single-fiber resolution using spatial transcriptomics.

    Main Methods:

    • Applied high-resolution Seq-Scope spatial transcriptomics to rodent extensor digitorum longus (EDL) and soleus (SOL) muscles.
    • Analyzed fiber-type-specific responses to mTORC1 hyperactivation and non-myocyte populations.

    Main Results:

    • mTORC1 hyperactivation induced distinct, fiber-type-dependent pathological programs in skeletal muscle.
    • Type IIx fibers showed opposing fates: hypertrophy in SOL and basophilia in EDL.
    • Type IIb fibers exhibited heterogeneity, including stress responses and developmental reprogramming.
    • Non-myocytes, like macrophages and fibroblasts, accumulated in SOL, promoting fibrosis and inflammation.

    Conclusions:

    • Sustained mTORC1 signaling disrupts muscle homeostasis via distinct metabolic and structural pathways.
    • This study links histopathological phenotypes to molecular states at single-fiber resolution, advancing myopathy research.