Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.3K
Internal Receptors01:31

Internal Receptors

74.3K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.3K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.3K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.7K
Overview
110.7K
Structures of Solids02:22

Structures of Solids

17.5K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.5K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

831
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
831

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms of VEGFR2 activation by VEGF, neuropilin, and heparin.

Science advances·2026
Same author

Structural insights into the activation of the chicken ROS1 receptor by the NEL/NICOL ligand complex.

Nature communications·2026
Same author

Publisher Correction: PtdIns(3,5)P<sub>2</sub> is an endogenous ligand of STING in innate immune signalling.

Nature·2026
Same author

Regulation of STING activation by phosphoinositide and cholesterol.

Nature·2026
Same author

PtdIns(3,5)P<sub>2</sub> is an endogenous ligand of STING in innate immune signalling.

Nature·2026
Same author

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.

Nature chemical biology·2026

Related Experiment Video

Updated: Jan 24, 2026

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study
12:43

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study

Published on: July 27, 2016

12.1K

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer.

Hui Zhang, Xiao-Chen Bai, Xuewu Zhang

    Biorxiv : the Preprint Server for Biology
    |January 23, 2026
    PubMed
    Summary

    Interleukin-17 receptors (IL-17Rs) form signal complexes with ACT1 via their SEFIR domains. This study reveals the cryo-EM structure, uncovering how IL-17RA and IL-17RB assemble with ACT1 to mediate immune signaling.

    More Related Videos

    A Protocol for the Production of KLRG1 Tetramer
    07:24

    A Protocol for the Production of KLRG1 Tetramer

    Published on: January 12, 2010

    10.3K
    ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
    07:31

    ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

    Published on: June 30, 2022

    2.9K

    Related Experiment Videos

    Last Updated: Jan 24, 2026

    Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study
    12:43

    Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study

    Published on: July 27, 2016

    12.1K
    A Protocol for the Production of KLRG1 Tetramer
    07:24

    A Protocol for the Production of KLRG1 Tetramer

    Published on: January 12, 2010

    10.3K
    ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
    07:31

    ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

    Published on: June 30, 2022

    2.9K

    Area of Science:

    • Immunology
    • Structural Biology
    • Molecular Biology

    Background:

    • Interleukin-17 receptors (IL-17Rs) are crucial for immune responses and inflammatory diseases.
    • IL-17Rs form heteromeric complexes that signal through the ACT1 transducer via SEFIR domain interactions.
    • The precise molecular mechanism of IL-17R-ACT1 complex formation and signaling remains elusive.

    Purpose of the Study:

    • To elucidate the molecular mechanism of IL-17 receptor signaling complex assembly.
    • To determine the cryo-electron microscopy (cryo-EM) structure of the IL-17RA, IL-17RB, and ACT1 complex.

    Main Methods:

    • Cryo-electron microscopy (cryo-EM) to determine the structure of the IL-17RA, IL-17RB, and ACT1 complex.
    • Mutational analyses to validate the proposed structural model.

    Main Results:

    • The cryo-EM structure reveals an asymmetric hetero-tetramer of IL-17RA and IL-17RB SEFIR domains.
    • IL-17RA SEFIR domains form the base for ACT1 recruitment, while IL-17RB stabilizes the IL-17RA dimer.
    • A double-stranded helical assembly of IL-17RB, IL-17RA, and multiple ACT1 molecules was observed, with IL-17RA's SEFEX domain anchoring ACT1.

    Conclusions:

    • The study reveals the structural basis for the IL-17 receptor-ACT1 signalosome formation.
    • This provides critical insights into the molecular mechanisms underlying IL-17-mediated immune signaling.