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Related Experiment Video

Updated: Jan 24, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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Functional Connectivity Graph Theory Analysis of Spoken Word Processing Efficiency in Prefrontal Cortical Activation.

Paulina Skolasinska, Adam T Eggebrecht, Julia L Evans

    Biorxiv : the Preprint Server for Biology
    |January 23, 2026
    PubMed
    Summary

    Functional near-infrared spectroscopy (fNIRS) and graph theory reveal brain network differences in spoken word processing. High performers show efficient brain networks, while low performers exhibit less efficient networks.

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    Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
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    Area of Science:

    • Neuroscience
    • Cognitive Science
    • Computational Linguistics

    Background:

    • Spoken word recognition is influenced by word frequency and phonotactic probability.
    • Understanding the neural basis of individual differences in spoken word processing is crucial.
    • Functional connectivity measures offer insights into brain network efficiency.

    Purpose of the Study:

    • To investigate if functional near-infrared spectroscopy (fNIRS) and graph theory can characterize spoken word processing efficiency in neurotypical listeners.
    • To assess individual differences in spoken word processing using functional connectivity measures (global efficiency, local efficiency, modularity, hubness) in the dorsolateral prefrontal cortex (DLPFC).
    • To explore the relationship between psycholinguistic models and direct measures of cognitive processing effort.

    Main Methods:

    • Twenty neurotypical participants (ages 18-21) completed an auditory working memory task involving words of varying frequency and phonotactic probability.
    • fNIRS recorded hemodynamic changes (HbO, HbR) in the prefrontal cortex.
    • Functional connectivity matrices were created using partial correlation coefficients, and graph theory measures were applied to analyze frontal networks.

    Main Results:

    • Task performance, not word frequency, correlated with brain measures: higher prefrontal functional connectivity (FC) related to worse accuracy, and high modularity correlated with slower response times.
    • High-performing individuals (High-P) exhibited low FC strength and high efficiency, while low-performing individuals (Low-P) showed high modularity and low efficiency.
    • Central brain regions ('hubs') were identified, with High-P individuals showing hubs overlapping with group-level consistent hubs, unlike Low-P individuals.

    Conclusions:

    • Network properties identified are related to efficient and inefficient spoken word processing in typical individuals.
    • These findings provide a basis for assessing language function in atypical populations.
    • Brain network characteristics, such as efficiency and modularity, are linked to behavioral performance in spoken word processing.