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Updated: Jan 24, 2026

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
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Ascorbate for Organ Dysfunction in Critically Ill Patients With Sepsis: The Phase 2b ASTER Trial

D Clark Files1, Michael A Matthay1, Lorraine B Ware1

  • 1Wake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

CHEST Critical Care
|January 23, 2026
PubMed
Summary

High-dose intravenous ascorbate did not improve organ support-free days in patients with sepsis and acute respiratory distress syndrome (ARDS). However, ascorbate did reduce inflammatory markers, suggesting potential benefits in sepsis and lung injury.

Keywords:
antioxidantlung injuryvitamin C

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