Endoscopic and histopathological findings in children with growth retardation
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View abstract on PubMed
Summary
This summary is machine-generated.Endoscopic evaluation revealed significant gastrointestinal findings in all children with persistent growth retardation, even without typical symptoms. These results highlight the importance of endoscopy in diagnosing underlying conditions contributing to poor growth in pediatric patients.
Area Of Science
- Pediatric Gastroenterology
- Clinical Nutrition
- Diagnostic Endoscopy
Background
- Growth retardation in children can stem from various underlying medical conditions.
- Adequate caloric support is crucial, but persistent growth issues warrant further investigation.
- Identifying the root cause of growth failure is essential for effective intervention.
Purpose Of The Study
- To characterize the clinical, endoscopic, and histopathological features of children experiencing growth retardation.
- To investigate the utility of upper gastrointestinal endoscopy in evaluating pediatric patients with persistent growth failure.
- To determine the prevalence of specific gastrointestinal conditions in this cohort.
Main Methods
- A cohort of 90 children (aged 2-18 years) with growth retardation, despite adequate caloric intake for at least 3 months, were included.
- All participants underwent oesophagogastroduodenoscopy (EGD) for diagnostic purposes.
- Clinical data, including nutritional status, symptoms, and laboratory results (celiac antibodies, iron, B12 levels), were collected and analyzed.
Main Results
- The majority of patients exhibited malnutrition (88.9%) and common endoscopic findings included pangastritis (88.9%), duodenitis (61.1%), and bile reflux (35.6%).
- Histopathological examination revealed high rates of chronic Helicobacter pylori gastritis (72.2%), celiac disease (20.0%), and reflux esophagitis (17.8%).
- Importantly, significant endoscopic findings were present in all children, irrespective of accompanying dyspeptic symptoms, and no association was found between H. pylori gastritis and nutritional status or deficiencies.
Conclusions
- Endoscopy is a valuable tool for identifying gastrointestinal pathologies in children with persistent growth retardation, even in the absence of overt symptoms.
- The findings underscore the need for considering endoscopic evaluation in the diagnostic workup of pediatric growth failure.
- Further research is warranted to fully elucidate the role and optimal application of endoscopy in this patient population.
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