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  1. Home
  2. Advancements In Research On Fluid Overload In Preterm Infants-a Narrative Review.
  1. Home
  2. Advancements In Research On Fluid Overload In Preterm Infants-a Narrative Review.

Related Experiment Video

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Advancements in research on fluid overload in preterm infants-a narrative review.

Xinyi Liu1,2,3, Shuyue Deng1,2,3, Siyu Chen1,2,3

  • 1Department of Neonatology, Children's Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Frontiers in Pediatrics
|January 23, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Fluid overload (FO) in preterm infants causes organ dysfunction. Effective management involves monitoring and fluid restriction, diuretics, and albumin for better neonatal outcomes.

Keywords:
adverse outcomefluid overloadmanagement of fluidsmechanismspreterm infant

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Area of Science:

  • Neonatalogy
  • Pediatric Nephrology
  • Critical Care Medicine

Background:

  • Fluid overload (FO) is a significant clinical issue in preterm infants, leading to multiorgan dysfunction and poor outcomes.
  • Understanding the pathophysiology of FO is crucial for improving management strategies in neonates.

Purpose of the Study:

  • To review the pathophysiology, clinical implications, and management of fluid overload in preterm infants.
  • To advance fluid management practices for preterm neonates.

Main Methods:

  • A narrative review of existing literature was conducted.
  • Literature was identified and data extracted based on the research question and inclusion criteria.
  • Studies cited in the review obtained institutional ethics committee approval and informed consent.

Main Results:

  • Pathogenesis of FO involves renal immaturity, skin barrier defects, glycocalyx damage, and hypoalbuminemia.
  • Noninvasive monitoring tools like echocardiography, bioelectrical impedance analysis (BIA), and lung ultrasound are clinically useful.
  • Effective management strategies include fluid restriction, diuretics, and albumin infusion.

Conclusions:

  • Optimizing FO management requires multimodal monitoring and tailored fluid regimens.
  • Future research should focus on refining assessment standards and developing targeted interventions for improved neonatal outcomes.