Related Experiment Video

Updated: Jan 24, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

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Advancements in research on fluid overload in preterm infants-a narrative review

Xinyi Liu1,2,3, Shuyue Deng1,2,3, Siyu Chen1,2,3

  • 1Department of Neonatology, Children's Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Frontiers in Pediatrics
|January 23, 2026
PubMed

Insights

Fluid overload (FO) in preterm infants causes organ dysfunction. Effective management involves monitoring and fluid restriction, diuretics, and albumin for better neonatal outcomes.

Area of Science:

  • Neonatalogy
  • Pediatric Nephrology
  • Critical Care Medicine

Background:

  • Fluid overload (FO) is a significant clinical issue in preterm infants, leading to multiorgan dysfunction and poor outcomes.
  • Understanding the pathophysiology of FO is crucial for improving management strategies in neonates.

Purpose of the Study:

  • To review the pathophysiology, clinical implications, and management of fluid overload in preterm infants.
  • To advance fluid management practices for preterm neonates.

Main Methods:

  • A narrative review of existing literature was conducted.
  • Literature was identified and data extracted based on the research question and inclusion criteria.
  • Studies cited in the review obtained institutional ethics committee approval and informed consent.

Main Results:

  • Pathogenesis of FO involves renal immaturity, skin barrier defects, glycocalyx damage, and hypoalbuminemia.
  • Noninvasive monitoring tools like echocardiography, bioelectrical impedance analysis (BIA), and lung ultrasound are clinically useful.
  • Effective management strategies include fluid restriction, diuretics, and albumin infusion.

Conclusions:

  • Optimizing FO management requires multimodal monitoring and tailored fluid regimens.
  • Future research should focus on refining assessment standards and developing targeted interventions for improved neonatal outcomes.
Abstract

Keywords:
adverse outcomefluid overloadmanagement of fluidsmechanismspreterm infant

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