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Updated: Jan 24, 2026
04:09
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
1.3K
Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and
Samaneh Esmaeili1, Majid Rahmati2, Majid Salehi3,4,5
1Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Summary
This study developed a novel hydrogel using Red Ginseng and Centella asiatica for advanced wound healing. The bioactive hydrogel promotes rapid tissue regeneration, fights infection, and reduces scarring.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Herbal Medicine
Background:
- Innovative smart hydrogel combines Red Ginseng (RG) and Centella asiatica for wound healing.
- Incorporates alginate and upcycled eggshell membrane for enhanced adhesion and sustainability.
- Addresses limitations of conventional hydrogels by promoting tissue regeneration and combating antibiotic-resistant infections.
Purpose of the Study:
- To develop and characterize a novel bioactive hydrogel for accelerated wound healing.
- To evaluate the synergistic effects of RG and Centella asiatica in a wound dressing.
- To assess the hydrogel's potential for eco-conscious wound care solutions.
Main Methods:
- Formulated hydrogels using sodium alginate, eggshell membrane, RG, and Centella asiatica.
- Assessed structural properties via SEM and FTIR; evaluated physical attributes including swelling, stability, and porosity.
- Investigated biocompatibility (hemolytic activity, cell viability) and therapeutic efficacy in a rat wound model (RNA expression, histology).
Main Results:
- The hydrogel displayed a porous structure promoting cell migration and exhibited significant antibacterial properties.
- MTT assays confirmed positive effects on cell proliferation without toxicity.
- In vivo studies showed accelerated wound closure, re-epithelialization, and enhanced gene expression compared to the control group.
Conclusions:
- The developed hydrogel effectively leverages RG and Centella asiatica for wound healing.
- Demonstrates potential for rapid wound closure, infection defense, and scar reduction.
- Represents a sustainable and bioactive approach to advanced wound care.
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