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Hybrid Zones

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Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.

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Updated: Jan 24, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Targeting EGFR With Quinazoline-4-One/Chalcone Hybrids: Design, Synthesis, and Anticancer Evaluation.

Yomna I El-Gazzar¹, Rasha Abdelhady^2,3, Nancy S Younis^4,5

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obour University for Science and Technology, Cairo, Egypt.

Archiv Der Pharmazie

|January 23, 2026

Summary

Novel quinazoline-4-one/chalcone hybrids show potent anticancer activity by inhibiting the epidermal growth factor receptor (EGFR). Compounds 4a and 4g demonstrated superior EGFR inhibition and induced apoptosis in cancer cells.

Keywords:

Chalcone EGFR inhibitors In silico studies Quinazoline‐4‐one anticancer activity

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Area of Science:

Medicinal Chemistry
Pharmacology
Cancer Biology

Background:

Epidermal Growth Factor Receptor (EGFR) is a key target in cancer therapy.
Developing novel EGFR inhibitors with enhanced anticancer activity is crucial.

Purpose of the Study:

To synthesize and evaluate novel quinazoline-4-one/chalcone hybrids as potential EGFR inhibitors.
To assess the anticancer activity of these compounds against human cancer cell lines.

Main Methods:

Chemical synthesis of quinazoline-4-one/chalcone hybrids (4a-4j).
In vitro evaluation of EGFR inhibition and anticancer activity against MCF-7 and HepG2 cell lines.
Molecular docking and dynamic simulation studies to understand binding interactions.

Main Results:

Compounds 4a and 4g exhibited potent EGFR inhibition (IC50 values of 0.09 µM and 0.10 µM, respectively), outperforming erlotinib.
These compounds demonstrated significant anticancer activity against both tested cancer cell lines.
Cell cycle arrest and apoptosis were observed in treated cancer cells.
Molecular docking confirmed binding to the EGFR active site, mimicking erlotinib's interaction.

Conclusions:

Novel quinazoline-4-one/chalcone hybrids, particularly 4a and 4g, are promising EGFR inhibitors with significant anticancer potential.
The observed biological activity is attributed to their specific binding interactions within the EGFR active site.
Further investigation supports their therapeutic utility in cancer treatment.