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Transcriptome Analysis of Circulating microRNAs Associated With Chagas Disease Susceptibility and Chronic Chagas

Eric Henrique Roma1, Fabielle Marques-Santos1,2, Alinne Rangel Dos Santos Renzetti1,2

  • 1Laboratório de Imunologia e Imunogenética em Doenças Infeciosas, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

The Journal of Infectious Diseases
|January 23, 2026
PubMed

Insights

Specific microRNAs are dysregulated in Chagas disease (ChD), indicating potential biomarkers for ChD susceptibility and chronic Chagas cardiomyopathy (CCC) severity.

Area of Science:

  • Molecular biology
  • Biomarker discovery
  • Cardiovascular research

Background:

  • Chagas disease (ChD) is a significant public health issue in Latin America.
  • Understanding ChD molecular mechanisms and identifying biomarkers is crucial for disease management.
  • Chronic Chagas cardiomyopathy (CCC) is a severe manifestation of ChD.

Purpose of the Study:

  • To investigate circulating microRNAs (miRNAs) linked to ChD susceptibility.
  • To identify miRNAs associated with the progression of chronic Chagas cardiomyopathy (CCC).

Main Methods:

  • Cross-sectional study involving 150 ChD patients and 42 controls.
  • MicroRNA sequencing to identify differentially expressed miRNAs (DEMs).
  • In silico functional analysis of identified DEMs.

Main Results:

  • Identified 40 DEMs between ChD patients and controls.
  • Upregulated miR-143-3p and miR-223-3p, downregulated miR-486-5p and miR-3960 in ChD patients.
  • Specific miRNAs showed differential expression correlating with CCC severity.

Conclusions:

  • Demonstrated specific microRNA dysregulation in Chagas disease.
  • Highlighted the potential of identified miRNAs as biomarkers for ChD susceptibility.
  • Indicated the utility of these miRNAs in assessing CCC severity.
Abstract

Keywords:
Chagas diseasecardiomyopathydisease progressionmicroRNAtranscriptome

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