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Developmental Disorders in Children Recently Diagnosed With Cancer
Jamie Shoag1,2,3, Long Vu4, Ritika Miryala2
1Cleveland Clinic, Cleveland, Ohio, USA.
None:
Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016-2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer-free controls. Pre-diagnosis, DD prevalence was similar (16% vs. 16.9%). However, post-diagnosis, children with cancer had over twice the risk of DD (ARR 2.09, 95% CI 1.55-2.83) across developmental domains. These findings reveal that DD emerges soon after cancer diagnosis, potentially related to treatment and/or secondary toxicities and highlight the need for early screening and rehabilitative intervention.
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