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PubMed
Summary
This summary is machine-generated.

Children diagnosed with cancer face a doubled risk of developmental disorders (DD) shortly after diagnosis. Early screening and intervention are crucial for these pediatric cancer patients.

Keywords:
childhood cancerdevelopmental disorderspsychosocialsurvivorship

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Area of Science:

  • Pediatric Oncology
  • Developmental Psychology
  • Public Health

Background:

  • Neurocognitive deficits are known in adult cancer survivors.
  • Developmental disorders (DD) emerging in children shortly after cancer diagnosis are less understood.

Purpose of the Study:

  • To investigate the prevalence and risk of developmental disorders in children following a cancer diagnosis.
  • To compare DD rates in pediatric cancer patients versus cancer-free children.

Main Methods:

  • Utilized linked Ohio cancer registry and Medicaid data from 2016-2019.
  • Compared DD prevalence in 324 children with cancer against 606,913 cancer-free controls.
  • Analyzed DD risk pre- and post-cancer diagnosis.

Main Results:

  • Pre-diagnosis DD prevalence was similar between groups (16% vs. 16.9%).
  • Post-diagnosis, children with cancer showed over double the risk of DD (ARR 2.09).
  • Increased DD risk was observed across multiple developmental domains.

Conclusions:

  • Developmental disorders emerge rapidly after a pediatric cancer diagnosis.
  • Treatment and secondary toxicities may contribute to the increased DD risk.
  • Highlights the necessity for early screening and rehabilitative interventions for pediatric cancer patients.