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Oncopreventive and Oncotherapeutic Potential of Plant Secondary Metabolites Against Gastric Cancer: A Review

Subhadas Chatterjee1,2, Sankhadip Bose2, Satarupa Acharjee3

  • 1Department of Pharmacy, Sanaka Educational Trust's Group of Institutions, Durgapur, West Bengal, India.

Phytotherapy Research : PTR
|January 23, 2026
PubMed

Insights

Phytochemicals like alkaloids and polyphenols show potential in preventing and treating gastric cancer by inhibiting cell growth and tumor progression. Further clinical trials are needed to confirm their therapeutic benefits.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Gastric cancer is a leading global health concern with limited treatment options.
  • Chemotherapy and immunotherapy for gastric cancer face challenges like side effects and variable efficacy.
  • Phytochemicals, derived from plants, offer a promising avenue for gastric cancer prevention and treatment.

Purpose of the Study:

  • To comprehensively review the preventive and therapeutic effects of phytochemicals against gastric cancer.
  • To elucidate the mechanisms of action underlying the anti-gastric cancer properties of phytochemicals.

Main Methods:

  • A structured literature search was conducted to gather preclinical and clinical data.
  • Data on phytochemicals' effects on gastric cancer cell proliferation, tumor growth, and molecular mechanisms were analyzed.

Main Results:

  • Alkaloids, glycosides, polyphenols, sulfur-containing compounds, and terpenoids demonstrated inhibition of gastric cancer cell proliferation and tumor growth.
  • Mechanisms include apoptosis induction, cell cycle arrest, autophagy promotion, epigenetic modifications, and modulation of key signaling pathways (e.g., NF-κB, MAPK, Wnt/β-catenin, PI3K/Akt/mTOR).

Conclusions:

  • Phytochemicals exhibit significant potential for gastric cancer prevention and therapy.
  • Further clinical research is essential to validate the efficacy and safety of phytochemicals for clinical application in gastric cancer treatment.
Keywords:
alkaloidsgastric cancerglycosidesmolecular mechanismspolyphenolssulfur compoundsterpenoids

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