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Updated: Jan 24, 2026
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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
Published on: June 7, 2020
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Modern Radiosurgery Approaches for Brain Metastases
Brittney Chau1, Eric Lin Chang, Adam Garsa
1Department of Radiation Oncology, University of Southern California Keck School of Medicine, Los Angeles, CA.
Cancer Journal (Sudbury, Mass.)
|January 23, 2026
Summary
Stereotactic radiosurgery (SRS) offers effective treatment for brain metastases, providing good local control and preserving neurocognition better than whole brain radiation therapy (WBRT). Further studies are exploring its expanded use.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Brain metastases impact up to 30% of cancer patients, causing neurological deficits.
- Multidisciplinary treatment involving surgery, radiation, and systemic therapy is crucial.
- Stereotactic radiosurgery (SRS) delivers focal high doses to tumors with minimal impact on surrounding tissue.
Purpose of the Study:
- To review the role and outcomes of Stereotactic Radiosurgery (SRS) in managing brain metastases.
- To compare SRS efficacy and neurocognitive preservation with Whole Brain Radiation Therapy (WBRT).
Main Methods:
- SRS application for intact brain metastases and postoperative cavities.
- Review of local control, survival outcomes, and neurocognitive preservation data.
- Identification of ongoing research into expanded SRS applications.
Main Results:
- SRS demonstrates good local control for brain metastases.
- Survival outcomes with SRS are comparable to WBRT.
- SRS offers superior preservation of neurocognition compared to WBRT.
Conclusions:
- SRS is an effective treatment modality for brain metastases, offering comparable survival and better neurocognitive outcomes than WBRT.
- Ongoing research is evaluating expanded indications for SRS, including preoperative use and in cases with multiple metastases.
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