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Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay
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How "Enhanced" Are Enhanced Influenza Vaccines for Neuraminidase? Antigen Content and Baseline Immunity Revisited

Xiaowei Zhang1

  • 1Department of Oncology, Xi'an Central Hospital, No. 161, West Fifth Road, Xincheng District, Xi'an 710061, Shaanxi, China.

The Journal of Infectious Diseases
|January 23, 2026
PubMed
Abstract

No abstract available in PubMed .

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Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
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Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...

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