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Updated: Jan 24, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience
Mark A Espeland1,2, Charles T Semelka1, Stephen B Kritchevsky1
1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
None:
The 10-year Action for Health in Diabetes (Look AHEAD) clinical trial compared a multidomain intensive lifestyle intervention to a diabetes support and education program with respect to major cardiovascular disease events (primary outcome) and other diabetes- and obesity-related outcomes. Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.
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