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Updated: Jan 24, 2026

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
Published on: November 13, 2021
A lateral flow immunoassay strip employing upconversion luminescence for quantitative detection of prostate-specific
Xinrui Yuan1, Zhengshuai Tang1, Fangfang Liu2,3
1School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Abstract:
A highly sensitive immunochromatographic test strip has been developed based on upconversion nanoparticles (UCNPs) for the quantitative detection of prostate-specific antigen (PSA). UCNPs exhibit distinctive anti-Stokes luminescence properties, enabling near-infrared excitation with visible light emission, which significantly reduces background autoluminescence and enhances signal clarity. The fabricated test strip demonstrated excellent sensitivity, specificity, and reproducibility in PSA detection, offering a promising platform for rapid, point-of-care testing. This approach holds potential for improving prostate cancer screening and real-time disease management in clinical and resource-limited settings.
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