Related Experiment Video

Updated: Jan 24, 2026

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.4K

The effect of mitomycin-C on 3 snip punctoplasty

Betül Dertsiz Kozan1, Bahadır Utlu2

  • 1Gazi Yasargil Training and Research Hospital, Ophthalmology, Diyarbakır, Turkey. dr.dertsiz@hotmail.com.

International Ophthalmology
|January 23, 2026
PubMed
Abstract

Insights

Mitomycin-C (MMC) use in 3 snip punctoplasty for epiphora improved surgical outcomes compared to no MMC. However, extending MMC application duration did not further enhance success rates in treating punctal stenosis.

Area of Science:

  • Ophthalmology
  • Surgical Techniques
  • Tear Drainage Disorders

Background:

  • Epiphora, or excessive tearing, is often caused by punctal stenosis.
  • 3 snip punctoplasty is a surgical technique to address punctal stenosis.
  • Mitomycin-C (MMC) is an antimetabolite agent sometimes used adjunctively in ophthalmic surgery.

Purpose of the Study:

  • To evaluate the impact of Mitomycin-C (MMC) application and its duration on the surgical success of 3 snip punctoplasty for epiphora.
  • To compare outcomes between 3 snip punctoplasty with and without MMC, and with varying MMC application times.

Main Methods:

  • Retrospective analysis of 90 patients (180 eyes) with epiphora due to punctal stenosis undergoing 3 snip punctoplasty.
  • Patients were divided into three groups: no MMC, 0.3% MMC for 1 minute, and 0.3% MMC for 2 minutes.
  • Surgical outcomes assessed included nasolacrimal passage patency and absence of epiphora post-surgery.

Main Results:

  • No significant difference in postoperative nasolacrimal passage closure was observed.
  • Success rates (no epiphora) were 80% without MMC, 90% with 1-minute MMC, and 93.3% with 2-minute MMC.
  • A statistically significant improvement in success was noted between the no-MMC group and the 1-minute MMC group (p<0.05), but not between the 1-minute and 2-minute MMC groups (p>0.05).

Conclusions:

  • 3 snip punctoplasty is an effective surgical treatment for punctal stenosis.
  • The use of Mitomycin-C (MMC) appears to enhance the success rate of 3 snip punctoplasty for epiphora.
  • Increasing the duration of MMC application beyond 1 minute does not yield additional significant benefits in surgical outcomes.
Keywords:
3 snipEpiphoraEyelidMitomycin-CPunctoplasty

More Related Videos

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells08:30

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells

Published on: March 19, 2017

17.1K
Growth and Electrostatic/chemical Properties of Metal/LaAlO3/SrTiO3 Heterostructures11:54

Growth and Electrostatic/chemical Properties of Metal/LaAlO3/SrTiO3 Heterostructures

Published on: February 8, 2018

10.7K

Related Concept Videos

ortho&ndash;para-Directing Activators: &ndash;CH3, &ndash;OH, &ndash;&NoBreak;NH2, &ndash;OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.3K
Piaget's Stage 3 of Cognitive Development01:17

Piaget's Stage 3 of Cognitive Development

During Piaget's concrete operational stage, from ages 7 to 11, children exhibit a marked increase in logical thinking skills, specifically in relation to tangible, real-world events. This stage is characterized by the development of several essential cognitive concepts, including conservation, reversibility, and classification, all of which support the child's evolving capacity for structured thought.
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
1.0K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
618
Electron Configuration of Multielectron Atoms03:26

Electron Configuration of Multielectron Atoms

The alkali metal sodium (atomic number 11) has one more electron than the neon atom. This electron must go into the lowest-energy subshell available, the 3s orbital, giving a 1s22s22p63s1 configuration. The electrons occupying the outermost shell orbital(s) (highest value of n) are called valence electrons, and those occupying the inner shell orbitals are called core electrons. Since the core electron shells correspond to noble gas electron configurations, we can abbreviate electron...
64.6K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

sp3d and sp3d 2 Hybridization
48.3K
Valence Bond Theory02:42

Valence Bond Theory

Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
11.2K