Related Experiment Video
Updated: Jan 24, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma
Mohamed Abdelaleim Abdelaziz1, Abdallah Mohammed Elagali2, Ayman S Soliman3
1Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Background:
It is challenging to diagnose hepatic cirrhosis and hepatocellular carcinoma (HCC) at an early stage since non-invasive markers are not specific and do not identify the early stage.
Objective:
Serum microRNA-192 could represent an early and critical pathogenetic factor in different liver diseases.
Methods:
92 participants were allocated into four equal groups (n = 23): control, compensated liver cirrhosis, decompensated cirrhosis, and HCC groups.
Results:
Decompensated cirrhosis and HCC showed significantly elevated Serum Alanine aminotransferase, aspartate aminotransferase, bilirubin, alpha-fetoprotein, and microRNA-192.
Conclusion:
Serum microRNA-192 can predict decompensated liver cirrhosis and HCC with high sensitivity and specificity.
Related Concept Videos
Viral Structure
RNA Editing
Viral Recombination
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Viral Mutations

