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TDRD3, a Tudor domain-containing protein, regulates Klf2-dependent Treg differentiation and function to modulate

Yun Shi1, Xiaoqun Tao2, Lei Shen2

  • 1Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

Science Advances
|January 23, 2026
PubMed
Summary

Tudor domain-containing protein 3 (TDRD3) is crucial for immune tolerance. Its absence impairs regulatory T cell differentiation and function, leading to inflammation and highlighting TDRD3 as a therapeutic target.

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