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Updated: Jan 25, 2026
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
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Genetic Testing in Prospective Kidney Donors: Current Evidence and Clinical Practice in Australia
Sadia Jahan1,2, Amali Mallawaarachchi3,4,5, Julia Jefferis2,6,7
1Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia.
Transplantation
|January 23, 2026
Summary
Genetic testing is crucial for living kidney donor assessment. This review offers a framework for integrating genetic testing into donor evaluations to improve donor safety and recipient access to transplants.
Area of Science:
- Nephrology
- Genetics
- Transplantation
Background:
- Genetic testing is moving from research to clinical practice.
- Limited guidance exists for integrating genomics into living kidney donor assessment.
- Genetic kidney diseases are a growing concern in transplantation.
Purpose of the Study:
- To provide an evidence-based framework for genetic testing in prospective living kidney donors in Australia.
- To guide the integration of genetic assessment into clinical practice.
- To optimize donor safety and recipient access to transplantation.
Main Methods:
- Review of current evidence and clinical guidelines.
- Development of a clinical algorithm for genetic assessment in potential living kidney donors.
- Emphasis on multidisciplinary team involvement and genetic counseling.
Main Results:
- Genetic assessment in donors requires prior diagnosis in the recipient.
- Cascade testing of related donors is essential but requires nuanced interpretation.
- Genetic testing should complement, not replace, traditional donor assessment.
Conclusions:
- A framework and clinical algorithm are proposed for genetic testing in living kidney donors.
- Shared decision-making in specialized clinics is recommended for uncertain risk cases.
- Key principles include genetic counseling, multidisciplinary teams, cascade testing, and equitable access.
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