Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K
Group Therapy01:26

Group Therapy

391
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
391
Psychodynamic Therapy01:29

Psychodynamic Therapy

542
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
542
Humanistic Therapy01:24

Humanistic Therapy

342
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
342

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical applications of MRI-based artificial intelligence in spinal metastases: A systematic review.

Journal of bone oncologyĀ·2026
Same author

Direct ink writing of tantalum: tailorable hierarchical porous scaffold for osteogenesis.

National science reviewĀ·2026
Same author

Bidirectional regulatory effects of frequency-dependent splenic apex electrical stimulation on peripheral immune suppression and central neural repair after spinal cord injury.

Neural regeneration researchĀ·2026
Same author

Artificial intelligence chatbots in response to patient's common inquiries about chordoma: A cross-sectional study.

Brain & spineĀ·2026
Same author

The potential of B7-H3 as a new target for CAR-T therapy: Advancements, challenges and clinical perspectives.

Cancer treatment and research communicationsĀ·2026
Same author

Clinical features and prognostic factors for spinal metastasis from sarcomatoid carcinoma: identifying candidates suitable for surgical intervention.

BMC musculoskeletal disordersĀ·2026

Related Experiment Video

Updated: Jan 25, 2026

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

1.0K

LRRC15 in tumorigenesis, progression, and therapy.

Jiaxue Zhu1, Jianru Xiao2

  • 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Department of Interventional Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China.

Cancer Treatment and Research Communications
|January 23, 2026
PubMed
Summary

Leucine-rich repeat-containing protein 15 (LRRC15) drives cancer progression and treatment resistance. Understanding LRRC15's role in the tumor microenvironment is key for developing new diagnostic and therapeutic strategies in oncology.

Keywords:
Antibody-drug conjugatesLRRC15Precision oncologyTherapeutic resistanceTumor microenvironmentTumor-stroma interactions

More Related Videos

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

20.9K
3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
10:51

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Published on: January 5, 2021

5.2K

Related Experiment Videos

Last Updated: Jan 25, 2026

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

1.0K
A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

20.9K
3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
10:51

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Published on: January 5, 2021

5.2K

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Leucine-rich repeat-containing protein 15 (LRRC15) is a transmembrane protein identified as a tumor-associated antigen in 2003.
  • LRRC15 is implicated in malignant phenotypes, therapeutic resistance, and immune evasion across various solid tumors.

Purpose of the Study:

  • To systematically review the molecular characteristics and regulatory functions of LRRC15.
  • To explore LRRC15's potential as a diagnostic biomarker and therapeutic target.
  • To elucidate LRRC15's mechanisms in tumor initiation, metastasis, immune regulation, and therapy resistance.

Main Methods:

  • Systematic literature review integrating genomics, proteomics, and single-cell sequencing data.
  • Analysis of clinical translational research findings.
  • Comprehensive elucidation of LRRC15's multifaceted mechanisms.

Main Results:

  • LRRC15 plays a significant role in the tumor microenvironment (TME).
  • LRRC15 influences tumor initiation, metastasis, immune evasion, and resistance to therapies.
  • Recent advancements provide deeper insights into LRRC15's complex functions.

Conclusions:

  • LRRC15 is a critical factor in cancer progression and therapeutic resistance.
  • LRRC15 presents a promising target for novel diagnostic and therapeutic strategies.
  • Further research into LRRC15 is essential for advancing precision oncology.