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Updated: Jan 25, 2026
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
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Clinical study on glymphatic system dysfunction in patients with temporal lobe epilepsy.
Yueer Qiu1, Yamei Lin2, Nuozhen Chen1
1Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350025, China; Department of Radiology, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian 350025, China.
Epilepsy & Behavior : E&B
|January 23, 2026
Summary
Glymphatic system (GS) dysfunction, indicated by weaker global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) coupling, is present in temporal lobe epilepsy (TLE). Larger choroid plexus (CP) volume predicts poor surgical outcomes in TLE patients.
Area of Science:
- Neuroscience
- Medical Imaging
- Epilepsy Research
Background:
- Glymphatic system (GS) dysfunction is implicated in various neurological disorders.
- Temporal lobe epilepsy (TLE) is a common form of epilepsy often associated with cognitive deficits.
- Understanding GS function in TLE is crucial for predicting disease progression and treatment outcomes.
Purpose of the Study:
- To investigate glymphatic system (GS) dysfunction in unilateral TLE patients.
- To assess the relationship between GS function (gBOLD-CSF coupling, choroid plexus [CP] volume) and TLE.
- To determine the predictive value of GS metrics for postsurgical outcomes in TLE.
Main Methods:
- Retrospective study of 64 TLE patients and 40 healthy controls (HC).
- Measured gBOLD-CSF coupling strength and choroid plexus (CP) volume.
- Analyzed correlations with clinical characteristics and structural metrics; logistic regression for predictive modeling.
Main Results:
- TLE patients exhibited weaker gBOLD-CSF coupling and larger CP volume than HC.
- Reduced gBOLD-CSF coupling was observed in both good and poor outcome groups.
- Larger CP volume was significantly associated with poor postsurgical outcomes and cerebral atrophy.
Conclusions:
- Patients with TLE demonstrate significant GS dysfunction linked to cerebral atrophy.
- Choroid plexus (CP) volume is an independent predictor of postsurgical seizure control.
- A combined model including CP volume, gray matter volume, and seizure history effectively predicts postsurgical outcomes.
Keywords:
Blood-oxygen-level-dependentCerebrospinal fluidChoroid plexusGlymphatic systemTemporal lobe epilepsyMore Related Videos
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