Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of Pediatric Mandibular Condyle Fracture and Malocclusion Using a Function-Generating Bite Appliance: A Case Report.

The American journal of case reports·2026

Same author

Association between cranial structure and choice of bolus hardness in an orthodontic sample.

The Angle orthodontist·2026

Same author

Evaluation of the Possible Correlation Between Dental Occlusion and Craniomandibular Disorders by Means of Teethan<sup>®</sup> Electromyography: Clinical-Observational Study on 20 Patients.

Journal of clinical medicine·2025

Same author

Enhancing cognition and well-being by treating the malocclusion unilateral posterior crossbite: preliminary evidence by a single case study.

AIMS neuroscience·2025

Same author

Functional treatment of unilateral posterior crossbite improves condylar asymmetry in mixed dentition patients.

European journal of orthodontics·2025

Same author

Stability of unilateral posterior crossbite treatment with the Function Generating Bite appliance : Association with reduction of mandibular clockwise rotation and increased maxillary transversal width measurements.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2024

Search research articles

Related Experiment Video

Updated: May 3, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognition".

Maria Grazia Piancino¹

¹Dental School, Department of Surgical Sciences, University of Turin, via Nizza 230, Turin 10126, Italy.

Archives of Oral Biology

|January 23, 2026

Summary

Chewing effectively preserves cognitive function by stimulating the hippocampus and increasing brain-derived neurotrophic factor (BDNF). Maintaining posterior teeth and seeking prosthodontic rehabilitation are crucial for both oral and neural health.

More Related Videos

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Related Experiment Videos

Last Updated: May 3, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Area of Science:

Neuroscience
Gerontology
Oral Health

Background:

Mastication (chewing) is increasingly recognized for its impact on cognitive function beyond its traditional role in food processing.
Evidence links masticatory function to brain health across the lifespan.

Purpose of the Study:

To review the scientific evidence connecting mastication and cognitive function.
To highlight the role of mastication in maintaining brain health and preventing cognitive decline.

Main Methods:

A narrative review of literature was performed.
Searches included PubMed, Scopus, and Web of Science databases.
Manual bibliographical searches were also conducted.

Main Results:

Chewing stimulates hippocampal neurogenesis, increasing neuronal density and brain-derived neurotrophic factor (BDNF), which enhances memory and cognition.
Studies in animals and humans, including elderly populations, support this link.
Adequate prosthodontic rehabilitation is associated with preserved cognitive function.
Loss of posterior teeth is particularly detrimental to effective mastication and cognitive health.
Mechanisms include exercise-induced myokines and neprilysin production, mediating neuroprotection.

Conclusions:

Mastication should be promoted as a preventive strategy for oral and neural health.
Public health initiatives should focus on maintaining posterior dentition and supporting prosthetic rehabilitation.
Promoting diets with adequate texture can sustain neuromuscular activity and protect cognitive function throughout life.