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The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
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Related Experiment Video

Updated: Jan 25, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Fin(e)-tuning ferroptosis.

Krystina Julia Szylo1, Scott James Dixon1

  • 1Department of Biology, Stanford University, Stanford, CA, USA.

Molecular Cell
|January 23, 2026
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Summary
This summary is machine-generated.

The anti-ferroptosis protein GPX4 uses a fin-loop to bind membranes. This fin-loop disruption in a rare disease causes neurodegeneration by uncoupling enzyme activity from biological function.

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Cell Biology

Background:

  • Ferroptosis is a regulated form of cell death.
  • GPX4 is a key regulator of ferroptosis, preventing cell death.
  • GPX4's membrane anchoring mechanism is crucial for its function.

Purpose of the Study:

  • To investigate the molecular mechanism of GPX4 membrane anchoring.
  • To understand how GPX4 dysfunction leads to neurodegeneration.
  • To explore the role of the "fin-loop" element in GPX4 activity.

Main Methods:

  • Structural biology techniques to analyze GPX4.
  • Biochemical assays to measure enzyme activity.
  • Cellular models to study ferroptosis and neurodegeneration.

Main Results:

  • GPX4 utilizes a unique "fin-loop" for membrane association.
  • Disruption of the fin-loop decouples GPX4's enzymatic activity from its biological role.
  • This decoupling is linked to an ultrarare human neurodegenerative disease.

Conclusions:

  • The fin-loop is essential for GPX4's membrane anchoring and biological function.
  • GPX4 dysfunction, specifically fin-loop disruption, is a cause of neurodegeneration.
  • This finding provides insights into ferroptosis regulation and neurodegenerative disease mechanisms.