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The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic target
Leire Bergara-Muguruza1, Kaan Gundogdu2, Izortze Santin3
1Department of Biochemistry and Molecular Biology, University of the Basque Country (EHU), Leioa, Spain; Biobizkaia Health Research Institute, Barakaldo, Spain.
Abstract:
The JAK-STAT signaling pathway is essential for regulating pro-inflammatory and immune responses across various cell types. Its involvement in inflammation has linked it to the pathogenesis of numerous autoimmune and inflammatory diseases. Genome-wide association studies have identified associations between JAK-STAT pathway genes and increased susceptibility to conditions such as type 1 diabetes, celiac disease, and multiple sclerosis. In recent years, this pathway has gained attention as a promising therapeutic target, leading to the development and clinical testing of several JAK-STAT inhibitors aimed at modulating immune-mediated inflammation. Despite notable progress in therapeutic modulation of the pathway, challenges remain in developing highly specific and effective drugs. Continued research is necessary to improve the precision and efficacy of treatments targeting the JAK-STAT pathway for autoimmune and inflammatory disorders.
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