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Updated: Jan 25, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Novel pyrazole bearing heterocyclic hybrids as promising biologically active compounds
Abstract:
The paper presents the results of a study devoted to the synthesis, evaluation of physicochemical properties, antiradical, and antimicrobial activity of pyrazole-containing heterocyclic hybrids. It has been shown that pyrazole bearing heterocyclic hybrids that contain quinazoline, triazoloquinazoline or triazole moieties are available via a series of reactions that include the interaction of 4-chloroquinazoline with pyrazole-containing hydrazides, cyclization of formed products into corresponding triazoloquinazolines, and hydrolytic cleavage of the electron-deficient tricyclic system. The structures of synthesized compounds have been verified by a complex of physicochemical methods, and the features of 1H NMR spectral characteristics have been described as well. The evaluation of obtained compounds' biological activity revealed a moderate bacteriostatic effect against Pseudomonas aeruginosa and Candida albicans, as well as high radical scavenging activity of some of the studied heterocyclic hybrids.
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