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Investigation of the Correlation between Different DCE-MRI Enhancement Patterns and Lymphovascular Invasion in
Shiqi Guo1, Boning Zhou2, Jiahong Sun1
1The Chinese People's Liberation Army (PLA) Medical College, Beijing 100853, China (S.G., B.Z., J.S., Q.L., S.C.); Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China (S.G., J.S., Y.X., Q.L., S.C., Z.G., J.W.).
Academic Radiology
|January 23, 2026
Summary
Non-mass enhancement (NME) on breast MRI is a significant risk factor for lymphovascular invasion (LVI) in invasive breast cancer. Certain subtypes like Luminal B, HER2-positive, and triple-negative also increase LVI risk, unlike ADC values.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Breast magnetic resonance imaging (MRI) is crucial for invasive breast cancer assessment.
- Enhancement patterns, including mass enhancement (ME) and non-mass enhancement (NME), are key imaging features.
- Lymphovascular invasion (LVI) is a critical prognostic factor in breast cancer.
Purpose of the Study:
- To compare breast MRI features and clinicopathological characteristics of invasive breast cancer based on enhancement patterns.
- To investigate the relationship between enhancement patterns and LVI.
- To identify independent risk factors for LVI.
Main Methods:
- Retrospective analysis of 1185 invasive breast cancer patients undergoing dynamic contrast-enhanced MRI (DCE-MRI).
- Propensity score matching (PSM) to compare ME and NME groups.
- Firth's bias-reduced logistic regression analysis to assess the association between enhancement patterns, clinicopathological factors, and LVI.
Main Results:
- Non-mass enhancement (NME) lesions showed significantly higher rates of LVI and axillary lymph node positivity compared to mass enhancement (ME) lesions.
- NME was identified as an independent risk factor for LVI (P<0.001).
- Luminal B, HER2-positive, and triple-negative subtypes were associated with increased LVI risk compared to Luminal A; ADC values showed no significant association with LVI.
Conclusions:
- Non-mass enhancement (NME) on breast MRI is a significant independent predictor of lymphovascular invasion (LVI) in invasive breast cancer.
- Specific molecular subtypes (Luminal B, HER2-positive, triple-negative) are associated with a higher risk of LVI.
- Apparent diffusion coefficient (ADC) values derived from MRI do not appear to be significantly associated with LVI risk.
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