Serum Interleukin-6 and Ventricular Tachycardia as Predictors of Mortality in Children With Fulminant Myocarditis
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View abstract on PubMed
Summary
This summary is machine-generated.Fulminant myocarditis in children has high mortality. High serum interleukin-6 (IL-6) levels and ventricular tachycardia (VT) on electrocardiogram accurately predict mortality risk in pediatric patients.
Area Of Science
- Pediatric Cardiology
- Critical Care Medicine
- Biomarkers in Disease
Background
- Fulminant myocarditis (FM) presents a significant mortality challenge in pediatric populations.
- Early identification of high-risk children is crucial for improving outcomes.
Purpose Of The Study
- To identify clinical indicators for early risk stratification in pediatric FM.
- To predict mortality in children diagnosed with FM.
Main Methods
- Retrospective analysis of 40 pediatric FM cases (2014-2024).
- Collected demographic, clinical, and vital sign data at admission and follow-up.
- Utilized logistic regression and ROC curve analysis to identify predictive factors.
Main Results
- Serum interleukin-6 (IL-6) and ventricular tachycardia (VT) were independently associated with mortality.
- High IL-6 levels (>24.60 pg/mL) showed 100% sensitivity and 97.1% specificity for predicting mortality.
- IL-6 levels correlated with disease severity markers.
Conclusions
- Serum IL-6 levels and VT on ECG are accurate predictors of mortality in pediatric FM.
- These indicators facilitate early identification of high-risk children.
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