Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...

Piaget's Stage 1 of Cognitive Development

Piaget's Stage 1 of Cognitive Development

The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...

PI Controller: Design

PI Controller: Design

Proportional Integral (PI) controllers are a fundamental component in modern control systems, widely used to enhance performance and mitigate steady-state errors. They are particularly effective in applications such as automatic brightness adjustment on smartphones, where they excel at mitigating steady-state errors for step-function inputs. Unlike PD controllers, which require time-varying errors to function optimally, PI controllers leverage their integral component to address residual...

The Buckingham Pi Theorem

The Buckingham Pi Theorem

The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.

Determination of Pi Terms

Determination of Pi Terms

The Buckingham Pi theorem is a valuable method in dimensional analysis, reducing complex relationships between variables into dimensionless terms. Relevant variables in analyzing the lift force on an airplane wing include lift force, air density, wing area, aircraft velocity, and air viscosity. Expressing each variable in terms of fundamental dimensions — mass, length, and time — provides a consistent foundation for constructing these dimensionless terms.
The theorem indicates that the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between <i>Helicobacter pylori</i> infection and colonic diverticulosis: a retrospective observational study in an asymptomatic Austrian endoscopy-based screening cohort.

BMJ open gastroenterology·2026

Same author

Changes in SSM Assessed via 100 Hz-VCTE Are Associated With Acute HVPG-Response to i.v. Propranolol: A European Multicentre Study.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Alcohol intake reprograms hepatic immune-metabolic circuits to exacerbate murine atherosclerosis and human cardiovascular risk.

JHEP reports : innovation in hepatology·2026

Same author

Stage-Specific Drivers of Clinical Progression in Advanced Chronic Liver Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026

Same author

A myeloid immunosuppressive phenotype defines primary refractoriness to atezolizumab plus bevacizumab in hepatocellular carcinoma.

Journal of hepatology·2026

Same author

Characterization of liver disease regression in murine models of liver fibrosis and portal hypertension.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: Jan 25, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With

Lorenz Balcar^1,2, Georg Semmler^1,2, Bernhard Scheiner^1,2

¹Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Alimentary Pharmacology & Therapeutics

|January 23, 2026

Summary

The SERPINA1 Pi*MZ genotype increases hepatocellular carcinoma (HCC) risk in patients with advanced chronic liver disease (ACLD). This genetic factor elevates HCC development independently of other known risk factors.

Keywords:

HCC PNPLA3 SERPINA1 cirrhosis portal hypertension

More Related Videos

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jan 25, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Published on: August 18, 2023

Area of Science:

Hepatology
Genetics
Oncology

Background:

The SERPINA1 Pi*Z allele causes alpha-1 antitrypsin deficiency-related liver disease.
The Pi*MZ genotype is a significant genetic risk factor for advanced chronic liver disease (ACLD).

Purpose of the Study:

To investigate the impact of the Pi*MZ genotype on hepatocellular carcinoma (HCC) development in patients with ACLD.
To determine if Pi*MZ genotype is an independent risk factor for HCC in ACLD patients.

Main Methods:

Included 815 ACLD patients without HCC undergoing HVPG measurement and genotyping.
Performed competing risk analyses with HCC as the outcome and death/liver transplantation as competing events.

Main Results:

4% of patients (30/815) had the Pi*MZ genotype.
Pi*MZ genotype was associated with increased HCC risk (aSHR: 3.31; p=0.015) in multivariable analyses.
This association remained significant after adjusting for the aMAP score (aSHR: 2.94; p=0.003).

Conclusions:

The SERPINA1 Pi*MZ genotype is an independent risk factor for HCC development in ACLD patients.
This finding highlights the importance of genetic screening for SERPINA1 in liver disease management.