Related Experiment Video
Updated: Jan 25, 2026

Screening of Tobacco Genotypes for Phytophthora nicotianae Resistance
Published on: April 15, 2022
A multiomics profile of coordinated defense and key candidate genes against bacterial wilt in tobacco
1Fujian Tobacco Agricultural science institute branch, Nanping Tobacco Monopoly Bureau, Nanping, 353000, China.
Abstract:
Bacterial wilt, caused by Ralstonia solanacearum, is a devastating disease that limits global tobacco production. To decipher the molecular basis of resistance, we conducted an integrated multiomics analysis of a susceptible cultivar, Honghua Dajinyuan (HD), and a moderately resistant cultivar, Yanyan 97 (YY), leveraging LC‒MS-based metabolomics and RNA-seq transcriptomics. The resistant YY cultivar exhibited coordinated multitiered defense, characterized by the accumulation of resistance-related metabolites (e.g., prenol lipids and organooxygen compounds) and the enrichment of plant hormone signaling pathways. Transcriptomic analysis revealed 818 differentially expressed genes (DEGs) involved in cell wall modification and stress responses. Crucially, the integration of weighted gene coexpression network analysis (WGCNA) with prior QTL mapping pinpointed Nta17g05760 within the qBWR17b locus as a core candidate gene. Our study systematically elucidates a defense network involving hormone signaling, cell wall reinforcement, and antimicrobial synthesis and provides a key candidate gene and theoretical foundation for the molecular breeding of wilt-resistant tobacco.
More Related Videos
Related Concept Videos
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Coordination of Gene Expression Processes in Bacteria
Coordination Number and Geometry
Coordination Compounds and Nomenclature
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
Key Techniques in Microbiology

