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Updated: Jan 25, 2026

Focal Laser Ablation of Prostate Cancer: An Office Procedure
Published on: March 30, 2021
MRI-guided laser ablation for pediatric intracranial pathology: single center experience
Margaret P Seaton1, Muhammad S Ghauri2, Kiefer J Forseth3
1Department of Neurological Surgery, University of California, San Diego, San Diego, CA, USA. mseaton@health.ucsd.edu.
Purpose:
This study evaluates the safety and efficacy of MR-guided laser interstitial thermal therapy (MRgLITT) in 88 consecutive pediatric patients involving lesional and non-lesional epilepsy, brain tumors, cavernous malformations, and other intracranial masses.
Methods:
A retrospective case series was performed on pediatric patients who underwent MRgLITT by the senior author between 2016 and 2024. Demographic, intraoperative, and outcome data were analyzed.
Results:
Eighty-eight patients (47 males, mean age 14.0 years) were included. Indications comprised epilepsy (68 patients, 80 procedures), brain tumors (25 patients, 26 procedures), and cavernous malformations (8 patients, 8 procedures). Complications occurred in 12 of 88 patients (13.6%), including three major complications (3.4%). Among epilepsy patients, 35 of 68 (51.5%) achieved an ILAE 1 outcome. Among tumor patients, 17 of 25 (68%) had no recurrence at latest follow-up. CCM patients had favorable clinical courses; among those with follow-up MRI, 6 of 7 demonstrated no residual lesion. Seizure outcomes did not differ significantly between lesional and non-lesional epilepsy cohorts: ILAE 1 outcomes occurred in 28 of 49 (57.1%) lesional versus 7 of 19 (36.8%) non-lesional patients. Reoperation was more frequent in non-lesional patients (6 of 19, 31.6%), though ultimate outcomes were comparable (p = 0.17). On multivariable analysis, higher social vulnerability index predicted poorer seizure outcomes, highlighting the impact of social determinants on surgical results.
Conclusions:
MRgLITT demonstrated favorable safety and indication-specific outcomes for pediatric epilepsy, tumors, and cavernous malformations in this single-surgeon series. These findings support its role as both a primary and adjuvant treatment in pediatric neurosurgery.
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