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Prefrontal Cortex Oxygenation Dynamics During Walking in Patients with Acute Stroke
Tomoya Takahashi1,2, Kentaro Iwata1, Kanji Yamada1
1Department of Rehabilitation, Kobe City Medical Center General Hospital, Kobe, Japan.
Advances in Experimental Medicine and Biology
|January 23, 2026
Summary
Cerebral oxygenation dynamics in acute stroke patients show decreased oxy-hemoglobin and increased deoxy-hemoglobin during walking, suggesting potential ischemia and vasoconstriction in the prefrontal cortex.
Area of Science:
- Neuroscience
- Cerebrovascular Research
- Rehabilitation Medicine
Background:
- Stroke significantly impacts cerebral hemodynamics and oxygenation.
- Understanding brain activity during functional tasks like walking is crucial for stroke recovery.
Purpose of the Study:
- To investigate cerebral oxygenation changes in the prefrontal cortex (PFC) during walking in acute stroke patients.
- To identify potential ischemia and vascular constriction during early post-stroke ambulation.
Main Methods:
- Near-infrared spectroscopy (NIRS) was used to measure oxy-hemoglobin (O₂Hb) and deoxy-hemoglobin (HHb) in the PFC.
- Fifty acute stroke patients walked for 70 seconds, with data compared to a pre-walking baseline.
- Statistical analysis included Friedman and Wilcoxon signed-rank tests with Bonferroni correction.
Main Results:
- Significant changes in O₂Hb, HHb, and total hemoglobin (THb) were observed during walking (p < 0.001).
- O₂Hb decreased at 40s, HHb increased at 45s, and THb decreased from 35s post-walking onset (p < 0.05).
Conclusions:
- Walking in the acute phase of stroke may induce cerebral ischemia and vascular constriction in the PFC.
- Findings suggest altered prefrontal cortex oxygenation dynamics during ambulation in acute stroke.
- Limitations include the absence of a control group and a focus solely on the PFC.
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