Association of baseline D-dimer with adverse outcomes after percutaneous coronary intervention in patients with coronary heart disease: A meta-analysis

Area of Science:

• Cardiology
• Biomarkers
• Interventional Cardiology

Background:

• Coronary heart disease (CHD) poses significant health risks.
• Percutaneous coronary intervention (PCI) is a common treatment for CHD.
• Predictive markers for adverse outcomes post-PCI are crucial for patient management.

Purpose of the Study:

• To evaluate the association between baseline D-dimers (DD) and adverse clinical outcomes following PCI in CHD patients.
• To synthesize evidence from multiple studies through meta-analysis.

Main Methods:

• A comprehensive literature search was conducted across major databases (PubMed, Web of Science, Cochrane Library, Embase) up to November 2024.
• Hazard ratios (HR) and 95% confidence intervals (CI) were pooled using fixed or random-effects models.
• Analyzed outcomes included all-cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), and revascularization.

Main Results:

• Ten studies were included in this meta-analysis.
• High baseline DD levels significantly correlated with increased risks of all-cause mortality (HR=2.35), cardiovascular mortality (HR=2.94), and MACE (HR=1.74).
• No significant association was observed between baseline DD levels and revascularization risk (HR=1.02).

Conclusions:

• Baseline D-dimer levels serve as a valuable predictor of adverse clinical outcomes in CHD patients undergoing PCI.
• Elevated baseline DD levels are strongly associated with higher risks of mortality and MACE post-PCI.