Related Experiment Video

Updated: Jan 25, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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Targeting the FOXM1/BUB1B signaling network in multiple myeloma: mechanistic insights and therapeutic potential

Durdana Yasin1, Neha Sami2, Sarah Khalid1

  • 1Department of Biosciences, Faculty of Science, Integral University, Lucknow, India.

Leukemia & Lymphoma
|January 24, 2026
PubMed

Insights

Multiple myeloma involves genomic instability and drug resistance, driven by the FOXM1 transcription factor and BUB1B kinase. Targeting this FOXM1-BUB1B pathway offers a promising strategy for treating aggressive plasma cell cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy marked by genomic instability and resistance to therapies.
  • Key drivers include the FOXM1 transcription factor and BUB1B kinase, which are linked to aggressive disease progression.
  • FOXM1 influences cell cycle and is upregulated by MAPK and PI3K/AKT pathways, while BUB1B is crucial for chromosome segregation.

Purpose of the Study:

  • To elucidate the functional relationship between FOXM1 and BUB1B in multiple myeloma.
  • To investigate the FOXM1-BUB1B axis as a potential therapeutic target for MM.
  • To explore the implications of this pathway in MM proliferation, drug resistance, and patient survival.

Main Methods:

  • Analysis of gene expression data and protein levels related to FOXM1 and BUB1B in MM.
  • Investigating the transcriptional regulation of BUB1B by FOXM1.
  • Preclinical evaluation of inhibitors targeting the FOXM1-BUB1B pathway.

Main Results:

  • FOXM1 directly regulates BUB1B transcription, establishing an oncogenic axis.
  • This FOXM1-BUB1B pathway significantly enhances MM cell proliferation, confers resistance to treatments, and promotes survival.
  • The pathway is associated with aggressive disease phenotypes.

Conclusions:

  • The FOXM1-BUB1B axis is a critical driver of multiple myeloma pathogenesis.
  • Targeting this pathway presents a promising therapeutic strategy for MM.
  • Further research is needed to validate clinical relevance, explore combination therapies, and assess biomarker potential.
Keywords:
BUB1BFoxM1Multiple myelomabiomarkerscell cycledrug resistance

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