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Updated: Jan 25, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Bilateral Globus Pallidus Deep Brain Stimulation Improves Motor Function in ADCY5-Related Disorder
Moritz Thiel1, Katerina Bernardi2, Enrique Gonzalez Saez-Diez2,3
1Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Background:
ADCY5-related disorder is characterized by disabling hyperkinetic movement disorders. The therapeutic impact of deep brain stimulation (DBS) has not been systematically evaluated.
Objectives/Methods:
This work involved a multicenter cohort study of 8 children with genetically confirmed ADCY5-related movement disorders treated with bilateral globus pallidus internus (GPi) DBS.
Results:
The mean age at initiation of DBS was 12.9 years (range: 3.5-18). All patients demonstrated improvement in baseline hyperkinesia and paroxysmal exacerbations. Mean Burke-Fahn-Marsden Dystonia Rating Scale motor scores decreased from 50.7 to 22.7 (p = 0.019, d = 1.19). Functional gains included new or recovered motor milestones, improved speech and swallowing, and resolution of sleep-related dyskinesias. There were no perioperative complications.
Conclusions:
GPi-DBS is a safe and effective therapy for ADCY5-related movement disorders, offering sustained motor and functional improvement. These findings support earlier consideration of DBS to reduce disease burden, preserve function, and improve long-term outcomes. © 2026 International Parkinson and Movement Disorder Society.
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